First, preheat the oven to 250 degrees F.
Second, add the cereal, crackers, nuts, and pretzels to a large bowl and toss to combine.
Third, in a separate bowl, combine the melted butter, Worcestershire sauce, hot sauce, garlic powder, onion powder, and Cavender's seasoning and whisk.
Next, pour the melted butter mixture on top of the cereal mixture and mix really well. (I like to use gloves and do this with my hands. That way I can make sure that every piece is covered in the butter and seasonings.)
Then, pour the Chex Mix onto the prepared baking sheet. (I used 2 large baking sheets, but you might want to use 3 to get the mix in a single layer.)
Bake the Chex mix for 2 hours, tossing and stirring it every 20 minutes.
Finally, remove the Chex mix from the oven, let it cool, place in an airtight container and enjoy!